Principia is bringing transformative therapies to patients with serious immune-mediated diseases by changing the way small molecules are developed. In 2017, Sanofi formed a collaboration with Principia under which Principia granted Sanofi an exclusive, worldwide license to develop and commercialize BTK inhibitor ‘168 in multiple sclerosis and other central nervous system diseases. The consummation of the tender offer is subject to customary closing conditions, including the tender of at least a majority of the outstanding shares of Principia common stock, the expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, and other customary conditions. Im Rahmen der Transaktion, die von den Boards beider Unternehmens einstimmig gebilligt wurde, plant Sanofi die Abgabe eines Übernahmeangebotes für alle ausstehenden Pincipia-Aktien in Höhe von 100 Dollar je Stück, wie der französische Pharmariese mitteilte. Die Transaktion soll … By continuing to browse this website, you agree to the use of such cookies. Zu den Schwerpunkten von Principia Biopharma gehört die Entwicklung von Behandlungen für immunvermittelte Krankheiten. The optimized target residence time has potential to deliver a desired efficacy with a stronger safety profile. Sanofi kauft US-Unternehmen Principia Biopharma, SANOFI-Aktie komplett kostenlos handeln - auf Smartbroker.de, Sanofi, Alnylam's hemophilia med fitusiran is on hold-again, UPDATE 2-Sanofi believes Europe well prepared to address pandemics, Sanofi continues to enroll patients for other diseases treatment - CEO, Sanofi has narrowed gap vs competitors in development of COVID-19 vaccine - CEO, Aktien Europa: Noch keine Schwäche auf hohem Niveau, Impressum | AGB | Disclaimer | Datenschutz. This highly reproducible approach enables the company to pursue multiple programs efficiently, having discovered three drug candidates. Centerview Partners LLC and BofA Securities, Inc. acted as financial advisors to Principia and Cooley LLP acted as its legal counsel. Following the successful completion of the tender offer, a wholly owned subsidiary of Sanofi will merge with Principia and the outstanding Principia shares not tendered in the tender offer will be converted into the right to receive the same $100 per share in cash paid in the tender offer. Principia’s Bruton tyrosine kinase (BTK) inhibitors add to Sanofi’s efforts to accelerate and build a portfolio of the next generation of transformative treatments for autoimmune diseases. “The Principia integration into Sanofi augments our small molecule research capabilities as we look to maintain leadership in the discovery and development of oral medicines for serious illnesses.”. Copyright (c) 2020 Dow Jones & Company, Inc. Sie erhalten auf FinanzNachrichten.de kostenlose Realtime-Aktienkurse von. By continuing to browse this website, you agree to the use of such cookies. Centerview Partners LLC and BofA Securities are acting as financial advisors to Principia and Cooley LLP is acting as its legal counsel. “Principia’s successful design and development of a whole portfolio of BTK inhibitors for immunology is aimed to transform the treatment for patients with immune-mediated diseases. Nach dem erfolgreichen Abschluss des Übernahmeangebots werde eine hundertprozentige Tochtergesellschaft von Sanofi mit Principia fusionieren. This website uses cookies to track its audience and improve its content. Evercore is acting as financial advisor to Sanofi and Weil, Gotshal & Manges LLP is acting as its legal counsel. PRN473 Topical, a topical reversible covalent BTK inhibitor designed for immune-mediated diseases that could benefit from localized application to the skin, is being evaluated in Phase 1 trials. Being able to block or disrupt these signaling processes can help in stopping inflammation and tissue destruction related to autoimmune diseases and target some of the underlying pathophysiology. Sanofi has announced that SAR442168 will be evaluated in four Phase 3 clinical trials in participants with relapsing and progressive forms of multiple sclerosis. Auch erhalte der Konzern die vollständige Kontrolle über den BTK-Hemmer SAR442168, der bei der Behandlung von Multipler Sklerose eingesetzt wird und derzeit an Sanofi lizenziert ist. Sanofi plans to finance the transaction with cash on hand. “The Phase 2b data in relapsing multiple sclerosis showed the strong potential of ‘168 to address disability and disease progression, and triggered the start of Phase 3 studies across the full spectrum of MS. The tender offer for all of the outstanding shares of Principia common stock expired as scheduled at one minute after 11:59 p.m., Eastern Time, on Friday, September 25, 2020. The webcast, conference call details, and full presentation will be made available on Sanofi’s Investor Relations webpage. PARIS – September 28, 2020 – Sanofi announced today the successful completion of its acquisition of Principia Biopharma Inc. (“Principia”) for $100 per share in cash. Rilzabrutinib, a reversible covalent BTK inhibitor, is being evaluated in a global Phase 3 clinical trial in participants with pemphigus, a Phase 1/2 clinical trial in participants with immune thrombocytopenia (ITP), and the company plans to initiate a Phase 2 clinical trial in participants with IgG4-Related Diseases and a Phase 3 trial in ITP. Sanofi will host an audio webcast live and conference call at 3:00 pm CET / 9:00 am ET on Monday, August 17, 2020. This website uses cookies to track its audience and improve its content. Click here for more information on cookies. The Sanofi and Principia Boards of Directors unanimously approved the transaction. The tender offer is expected to commence later this month. Die Übernahme werde die Forschung und Entwicklung in Bereichen wie Autoimmun- und allergische Krankheiten stärken, teilte Sanofi weiter mit. Sanofi completes Principia Biopharma Inc. acquisition, *Principia Biopharma Inc. is now a wholly owned subsidiary of Sanofi. BTK is present in the signaling pathways of key innate and adaptive cell types of the immune system. Subject to the satisfaction or waiver of customary closing conditions, Sanofi expects to complete the acquisition in the fourth quarter of 2020. Sanofi to commence tender offer for acquisition of Principia Biopharma Inc. Paris, August 28 2020 - Sanofi announced today that it intends to commence a tender offer (the “Offer”) today to acquire all of the outstanding shares of common stock of Principia Biopharma Inc. (“Principia”) for $100 per share in cash, without interest thereon and net of any applicable withholding taxes. Die Transaktion soll im vierten Quartal abgeschlossen werden. Under the terms of the merger agreement, Sanofi will commence a cash tender offer to acquire all outstanding shares of Principia common stock for $100 per share in cash for a total enterprise value of approximately $3.36 billion. By combining with Sanofi, we will bring significant resources to expand and accelerate the potential benefits of these therapies. Following its acceptance of the tendered shares, Sanofi completed its acquisition of Principia through the merger of Purchaser with and into Principia, pursuant to Section 251(h) of the General Corporation Law of the State of Delaware, with Principia continuing as the surviving corporation and becoming an indirect, wholly owned subsidiary of Sanofi. The merger will provide global resources to get these novel therapies to patients faster,” said Martin Babler, President and CEO at Principia Biopharma. At Principia Biopharma, a Sanofi company, we are focused on bringing transformative therapies to patients with serious immune-mediated diseases by changing the way small molecules are developed. “This acquisition advances our ongoing R&D transformation to accelerate development of the most promising medicines that will address significant patient needs,” said Paul Hudson, Sanofi Chief Executive Officer. Through Principia’s proprietary Tailored Covalency® platform, our strategy is to build and advance a pipeline of best-in-class drug candidates with significant therapeutic benefits, limit unintended side effects, improve quality of life and over time modify the course of disease. Our mission is to make best-in-class medicines to address unmet medical needs by changing the way small molecule drugs are designed. Principia common stock will cease to be traded on the NASDAQ Global Select Stock Market. For more information, please visit www.principiabio.com. Wie bewerten Sie die aktuell angezeigte Seite? About Principia BiopharmaPrincipia is a late-stage biopharmaceutical company dedicated to bringing transformative therapies to patients with significant unmet medical needs in immune-mediated diseases. PARIS/LONDON (dpa-AFX) - Europas Aktienmärkte haben am Mittwoch auf hohem Niveau etwas zugelegt. Click here for more information on cookies, Further strengthens core R&D areas of autoimmune and allergic diseases, Provides full control of brain-penetrant BTK inhibitor SAR442168 in multiple sclerosis (MS), making commercialization more efficient and eliminating future royalty payments, Allows expansion of SAR442168 development program into other central nervous system diseases and therapeutic areas, Adds clinically advanced oral BTK inhibitor rilzabrutinib with potential across a range of immunology and inflammation indications, complementing Sanofi’s existing R&D pipeline. PARIS and SOUTH SAN FRANCISCO, Calif. – August 17, 2020 – Sanofi and Principia Biopharma Inc. (NASDAQ: PRNB), a late-stage biopharmaceutical company focused on developing treatments for immune-mediated diseases, entered into a definitive agreement under which Sanofi will acquire all of the outstanding shares of Principia for $100 per share in cash, which represents an … Both ‘168 and rilzabrutinib, have ‘pipeline in a product’ potential, and we look forward to unlocking their full treatment benefits across an array of diseases,” said John Reed, M.D., Ph.D., Global Head of Research & Development at Sanofi. The minimum tender condition and all of the other conditions to the offer have been satisfied and on September 28, 2020, Sanofi and its wholly owned subsidiary Kortex Acquisition Corp. (“Purchaser”), accepted for payment and will promptly pay for all shares validly tendered and not validly withdrawn. PRN2246/SAR442168 is a covalent BTK inhibitor which crosses the blood-brain barrier and is licensed to Sanofi. Die Andienungsfrist soll noch im Laufe dieses Monates beginnen. PARIS – September 28, 2020 – Sanofi announced today the successful completion of its acquisition of Principia Biopharma Inc. (“Principia”) for $100 per share in cash.

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